Tandospirone hydrochloride (Metanopirone), 5-HT1A partial agonist (ab146136)
Key features and details
- Potent, selective 5-HT1A partial agonist
- CAS Number: 99095-10-0
- Purity: > 99%
- Soluble in water to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Tandospirone hydrochloride (Metanopirone), 5-HT1A partial agonist -
Description
Potent, selective 5-HT1A partial agonist -
Biological description
Potent, selective 5-HT1A partial agonist (Ki = 27 nM). Decreases the firing rate of 5-HT neurons of the dorsal raphe. Shows anxiolytic and antidepressant effects in vivo. Orally active.
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Purity
> 99% -
CAS Number
99095-10-0 -
Chemical structure
Properties
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Chemical name
(3aR,4S,7R,7aS)-rel-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione hydrochloride -
Molecular weight
419.95 -
Molecular formula
C21H29N5O2.HCl -
PubChem identifier
13422623 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1C[C@H]2C[C@@H]1[C@H]3[C@@H]2C(=O)N(C3=O)CCCCN4CCN(CC4)C5=NC=CC=N5.Cl -
Source
Synthetic
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Research areas
