Suramin hexasodium salt, non-selective P2 purinergic antagonist (ab120422)
Key features and details
- Non-selective P2 purinergic antagonist
- CAS Number: 129-46-4
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Suramin hexasodium salt, non-selective P2 purinergic antagonist -
Description
Non-selective P2 purinergic antagonist -
Biological description
Non-selective P2 purinergic antagonist (pEC50 values are 4.5 (P2X2), 5.4 (P2X5), 4.3 (P2Y2), 4.0 (P2Y4) and 4.8 (P2Y11)). Displays diverse biological actions. Shows antitumor activity, inhibits binding of multiple growth factors and additionally inhibits glutamatergic synaptic transmission.
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Purity
> 99% -
CAS Number
129-46-4 -
Chemical structure
Properties
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Chemical name
8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt -
Molecular weight
1429.16 -
Molecular formula
C51H34N6Na6O23S6 -
PubChem identifier
8514 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])C.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+] -
Source
Synthetic
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Research areas
Images
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Functional Studies - Suramin hexasodium salt, non-selective P2 purinergic antagonist (ab120422) Tchernookova et al PLoS One. 2018 Feb 21;13(2):e0190893. doi: 10.1371/journal.pone.0190893. eCollection 2018. Fig 2. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/
Inhibition by suramin, PPADS and DIDS significantly reduces the ATP-induced increase in extracellular H+ flux from isolated Müller cells.
(A) A representative trace from a single Müller cell shows a significant increase in H+ flux in response to 10 μM ATP that is significantly reduced by the ATP receptor blockers 200 μM PPADS and 200 μM suramin; asterisk indicates a background control reading. (B) 300 μM DIDS, which inhibits anion transport, significantly reduces the increase in H+ flux in response to 10 μM ATP. (C) Mean responses to 10 μM ATP with or without suramin and PPADS in the bath; N = 7, error bars represent SEMs. (D) Mean responses to 10 μM ATP in the presence of 300 μM DIDS (N = 6) and in the absence of DIDS, N = 5 (controls).
