SR144528, peripheral CB2 receptor inverse agonist (ab146185)
Key features and details
- Potent, selective peripheral CB2 receptor inverse agonist
- CAS Number: 192703-06-3
- Purity: > 98%
Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SR144528, peripheral CB2 receptor inverse agonist -
Description
Potent, selective peripheral CB2 receptor inverse agonist -
Biological description
Potent, selective peripheral CB2 receptor inverse agonist (Ki values are 0.6 and 400 nM for CB2 and CB1 receptors respectively). Decreases µ-opioid receptor expression. Enhances gastric motility in vivo.
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Purity
> 98% -
CAS Number
192703-06-3 -
Chemical structure
Properties
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Chemical name
5-(4-Chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1R,3S,4S)-2,2,4-trimethyl-3-bicyclo[2.2.1]heptanyl]pyrazole-3-carboxamide
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Molecular weight
476.05 -
Molecular formula
C29H34ClN3O -
PubChem identifier
3081355 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 100 mM and in DMSO to 100 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=CC=C(C=C1)CN2C(=CC(=N2)C(=O)N[C@H]3[C@]4(CC[C@H](C4)C3(C)C)C)C5=CC(=C(C=C5)Cl)C -
Source
Synthetic
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Research areas