SR1001, RORalpha and RORgammat inverse agonist (ab141462)
Key features and details
- Potent, selective RORα and RORγt inverse agonist
- CAS Number: 1335106-03-0
- Purity: > 98%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SR1001, RORalpha and RORgammat inverse agonist -
Description
Potent, selective RORα and RORγt inverse agonist -
Biological description
Potent, selective RORα and RORγt inverse agonist (Ki values are 172 and 111 nM for RORα and RORγ respectively). Suppresses IL-17 promoter driven transcriptional activity. Inhibits TRAP220 nuclear receptor box 2 peptide interaction (IC50 = 117 nM). Shows immunosuppressant effects in vivo. -
Purity
> 98% -
CAS Number
1335106-03-0 -
Chemical structure
Properties
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Chemical name
N-(5-(N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)sulfamoyl)-4-methylthiazol-2-yl)acetamide -
Molecular weight
477.39 -
Molecular formula
C15H13F6N3O4S2 -
PubChem identifier
44241473 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C(SC(=N1)NC(=O)C)S(=O)(=O)NC2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O -
Source
Synthetic
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Research areas
