Sotrastaurin, pan-PKC inhibitor (ab219867)
Key features and details
- Potent, selective pan-PKC inhibitor
- CAS Number: 425637-18-9
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Sotrastaurin, pan-PKC inhibitor -
Description
Potent, selective pan-PKC inhibitor -
Alternative names
- 3-(1H-indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione
- AEB071
- NVP-AEB071
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Biological description
Potent, selective pan-PKC inhibitor (Ki values of 0.95, 0.64, 2.1, 3.2, 1.8, and 0.22 nM for PKCα, βI, δ, ε, η, and θ respectively in a cell-free assay). Prevents the production of various cytokines by activated T cells, macrophages, and keratinocytes in vitro and has been shown to inhibit an acute allergic contact dermatitis response in rats when dosed orally at 30 mg. Displays potential immunosuppressive activity.
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CAS Number
425637-18-9 -
Chemical structure
Properties
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Molecular weight
438.48 -
Molecular formula
C25H22N6O2 -
PubChem identifier
10296883 -
Storage instructions
Store at -20°C. Store under desiccating conditions. -
SMILES
CN1CCN(CC1)C2=NC3=CC=CC=C3C(=N2)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65 -
Source
Synthetic
