Sonidegib (NVP-LDE225, Erismodegib), smoothened (Smo) antagonist (ab269876)
Key features and details
- Potent and selective Smoothened antagonist
- CAS Number: 956697-53-3
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Sonidegib (NVP-LDE225, Erismodegib), smoothened (Smo) antagonist -
Description
Potent and selective Smoothened antagonist -
Biological description
Potent and selective Smoothened antagonist. Blocks Hedgehog signaling pathway activity (IC50 = 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays. Anti-tumor activity in mouse medulloblastoma allograft model.
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CAS Number
956697-53-3 -
Chemical structure
Properties
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Chemical name
rel-N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'- (trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide -
Molecular weight
485.50 -
Molecular formula
C26H26F3N3O3 -
PubChem identifier
24775005 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Toxic, refer to SDS for further information.
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SMILES
C[C@@H]1CN(C[C@@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F -
Source
Synthetic
Images
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Chemical Structure - Sonidegib (NVP-LDE225, Erismodegib), smoothened (Smo) antagonist (ab269876)
Chemical structure of Sonidegib (NVP-LDE225, Erismodegib), smoothened (Smo) antagonist, 956697-53-3