Serabelisib, phosphoinositide 3-kinase alpha inhibitor (ab235549)
Key features and details
- Potent, selective phosphoinositide 3-kinase α inhibitor
- CAS Number: 1268454-23-4
- Purity: > 98%
Soluble in DMSO to 44.03 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Serabelisib, phosphoinositide 3-kinase alpha inhibitor -
Description
Potent, selective phosphoinositide 3-kinase α inhibitor -
Alternative names
- INK-1117
- INK1117
- MLN-1117
see all -
Biological description
Potent, selective phosphoinositide 3-kinase α (PI3Kα) inhibitor (IC50 =15nM for PI3Kα vs. >1 µM for other isoforms in vitro). 100-fold selectivity relative to other class I PI3K family members and mTOR as well as a high degree of selectivity against a large panel of protein kinases. Orally bioavailable.
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Purity
> 98% -
CAS Number
1268454-23-4 -
Chemical structure
Properties
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Chemical name
[6-(2-amino-5-benzoxazolyl)imidazo[1,2-a]pyridin-3-yl]-4-morpholinyl-methanone
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Molecular weight
363.34 -
Molecular formula
C19H17N5O3 -
PubChem identifier
70798655 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 44.03 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1COCCN1C(=O)C2=CN=C3N2C=C(C=C3)C4=CC5=C(C=C4)OC(=N5)N -
Source
Synthetic
