SAG (Smo agonist), Smoothened agonist (ab142160)
Key features and details
- Cell-permeable, selective, potent Smoothened agonist
- CAS Number: 912545-86-9
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SAG (Smo agonist), Smoothened agonist -
Description
Cell-permeable, selective, potent Smoothened agonist -
Biological description
Cell-permeable, selective, potent Smoothened agonist (EC50 = 3 nM). Binds the Smo heptahelical bundle that antagonizes cyclopamine (ab120392) action. Active in vitro and in vivo.
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Purity
> 98% -
CAS Number
912545-86-9 -
Chemical structure
Properties
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Chemical name
3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide -
Molecular weight
490.06 -
Molecular formula
C28H28ClN3OS -
PubChem identifier
5284330 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN[C@H]1CC[C@@H](CC1)N(Cc2ccc(cc2)c3ccncc3)C(=O)c5sc4ccccc4c5Cl -
Source
Synthetic
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Research areas