SAG hydrochloride, Smo activator (ab145866)
Key features and details
- Potent Smo activator
- CAS Number: 912545-86-9
- Purity: > 98%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
SAG hydrochloride, Smo activator -
Description
Potent Smo activator -
Biological description
Potent Smo activator (EC50 = 3 nM, NIH 3T3-derived Shh-LIGHT2 cells). Interacts with the heptahelical domain (Kd = 59 nM). Behaves as an activator at low concentrations and as an inhibitor at high concentrations. Water soluble version of SAG (ab142160).
-
Purity
> 98% -
CAS Number
912545-86-9 -
Chemical structure
Properties
-
Chemical name
3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide dihydrochloride -
Molecular weight
562.98 -
Molecular formula
C28H28ClN3OS.2HCl -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
Cl.Cl.CN[C@H]1CC[C@@H](CC1)N(Cc2ccc(cc2)c3ccncc3)C(=O)c5sc4ccccc4c5Cl -
Source
Synthetic
