S3I-201, STAT3 inhibitor (ab141434)
Key features and details
- Novel, selective STAT3 inhibitor
- CAS Number: 501919-59-1
- Purity: > 97%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
S3I-201, STAT3 inhibitor -
Description
Novel, selective STAT3 inhibitor -
Alternative names
- NSC 74859
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Biological description
Novel, selective STAT3 inhibitor (IC50 values are 86 (STAT3.STAT3), 160 (STAT1.STAT3), 166 (STAT1.STAT1) and >300 μM (STAT5.STAT5) for DNA-binding activity). Inhibits complex formation, STAT3 tyrosine phosphorylation and DNA-binding. Inhibits growth and induces apoptosis. Antitumor activity in vivo. -
Purity
> 97% -
CAS Number
501919-59-1 -
Chemical structure
Properties
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Chemical name
2-Hydroxy-4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid -
Molecular weight
365.36 -
Molecular formula
C16H15NO7S -
PubChem identifier
252682 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O -
Source
Synthetic
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Research areas
