(S)-CR8, CDK 1, 2, 5, 7 and 9 inhibitor (ab144231)
Key features and details
- Potent, selective, cell-permeable cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor
- CAS Number: 1084893-56-0
- Purity: > 98%
- Soluble in ethanol to 25 mM and in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
(S)-CR8, CDK 1, 2, 5, 7 and 9 inhibitor -
Description
Potent, selective, cell-permeable cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor -
Biological description
Potent, selective, cell-permeable cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor (IC50 = 41 - 400 nM). (R)-DRF053 (ab141505) analog. More potent than roscovirtine. Apoptosis inducer. GSK-3α/β (glycogen synthase kinase-3α/β) inhibitor. Antitumor potential.
See similar compound -
Purity
> 98% -
CAS Number
1084893-56-0 -
Chemical structure
Properties
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Chemical name
(2S)-2-[[9-Propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]butan-1-ol -
Molecular weight
431.53 -
Molecular formula
C24H29N7O -
PubChem identifier
25211051 -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Soluble in ethanol to 25 mM and in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC[C@@H](CO)NC1=NC2=C(C(=N1)NCC3=CC=C(C=C3)C4=CC=CC=N4)N=CN2C(C)C -
Source
Synthetic
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Research areas