Rotenone, mitochondrial electron transport chain inhibitor (ab143145)
Key features and details
- Mitochondrial electron transport chain complex I inhibitor. Potent NADH oxidation inhibitor.
- CAS Number: 83-79-4
- Purity: > 97%
- Soluble in ethanol to 5 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Rotenone, mitochondrial electron transport chain inhibitor -
Description
Mitochondrial electron transport chain complex I inhibitor. Potent NADH oxidation inhibitor. -
Biological description
Mitochondrial electron transport chain complex I inhibitor (IC50 values are 1.7 - 2.2 µM). Potent NADH oxidation inhibitor (IC50 = 3.4 nM). Suppresses microtubule assembly. Induces BRL cell apoptosis. Shows antiproliferative effects. Shows central effects. Induces parkinsonian behavior in vivo.
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Purity
> 97% -
CAS Number
83-79-4 -
Chemical structure
Properties
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Chemical name
(2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one -
Molecular weight
394.42 -
Molecular formula
C23H22O6 -
PubChem identifier
6758 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 5 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(=C)[C@H]1CC2=C(O1)C=CC3=C2O[C@@H]4COC5=CC(=C(C=C5[C@@H]4C3=O)OC)OC -
Source
Synthetic