Ro 61-8048, kynurenine 3-monooxygenase (KMO) inhibitor (ab141466)
Key features and details
- Potent, competitive kynurenine 3-monooxygenase (KMO) inhibitor
- CAS Number: 199666-03-0
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ro 61-8048, kynurenine 3-monooxygenase (KMO) inhibitor -
Description
Potent, competitive kynurenine 3-monooxygenase (KMO) inhibitor -
Biological description
Potent and competitive kynurenine 3-hydroxylase inhibitor (IC50 = 37 nM). Shows antidystonic, anticonvulsant and neuroprotective effects in vivo. Orally active.
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Purity
> 98% -
CAS Number
199666-03-0 -
Chemical structure
Properties
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Chemical name
3,4-Dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide -
Molecular weight
421.45 -
Molecular formula
C17H15N3O6S2 -
PubChem identifier
5282337 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=C(C=C(C=C1)S(=O)(=O)NC2=NC(=CS2)C3=CC(=CC=C3)[N+](=O)[O-])OC -
Source
Synthetic
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Research areas
