RG7388, p53-MDM2 interaction inhibitor (ab219378)
Key features and details
- Potent, selective inhibitor of p53-MDM2 interaction
- CAS Number: 1229705-06-9
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 10 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
RG7388, p53-MDM2 interaction inhibitor -
Description
Potent, selective inhibitor of p53-MDM2 interaction -
Alternative names
- Idasanutlin
- RG 7388
- RO 5503781
- RO5503781
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Biological description
Potent, selective inhibitor of p53-MDM2 interaction. Blocks p53−MDM2 binding and effectively activates the p53 pathway, leading to cell cycle arrest and/or apoptosis in cell lines expressing wild-type p53 and tumor growth inhibition or regression of osteosarcoma xenografts in nude mice.
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Purity
> 99% -
CAS Number
1229705-06-9 -
Chemical structure
Properties
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Chemical name
4-[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino]-3-methoxybenzoic acid -
Molecular weight
616.48 -
Molecular formula
C31N29Cl2F2N3O4 -
PubChem identifier
53358942 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 10 mM (with warming) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)(C)C[C@H]1[C@]([C@H]([C@@H](N1)C(=O)NC2=C(C=C(C=C2)C(=O)O)OC)C3=C(C(=CC=C3)Cl)F)(C#N)C4=C(C=C(C=C4)Cl)F -
Source
Synthetic
