VU0152100, M4 positive allosteric modulator (ab141510)
Key features and details
- Potent and selective M4 positive allosteric modulator
- CAS Number: 409351-28-6
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
VU0152100, M4 positive allosteric modulator -
Description
Potent and selective M4 positive allosteric modulator -
Biological description
Potent and selective M4 mAChr positive allosteric modulator (IC50 = 380 nM). Does not possess intrinsic agonist activity. Inhibits behavioural and neurochemical effects of cocaine. Active in vivo.
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Purity
> 99% -
CAS Number
409351-28-6 -
Chemical structure
Properties
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Chemical name
3-Amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide -
Molecular weight
341.43 -
Molecular formula
C18H19N3O2S -
PubChem identifier
864492 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COc1ccc(cc1)CNC(=O)c3sc2nc(C)cc(C)c2c3N -
Source
Synthetic
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Research areas