Recombinant mouse IL-1 alpha protein (ab119727)
Key features and details
- Expression system: Escherichia coli
- Purity: > 98% SDS-PAGE
- Active: Yes
- Suitable for: HPLC, SDS-PAGE, Functional Studies
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Product name
Recombinant mouse IL-1 alpha protein
See all IL-1 alpha proteins and peptides -
Biological activity
The ED50 as determined by the dose-dependent stimulation of the proliferation of murine D10S cells was found to be 8 IU/mg. -
Purity
> 98 % SDS-PAGE.
Purity: > 98% by SDS-PAGE and HPLC analysis. Endotoxin level is -
Expression system
Escherichia coli -
Accession
-
Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Mouse -
Predicted molecular weight
18 kDa -
Amino acids
115 to 270
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Preparation and Storage
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Alternative names
- BAF
- FAF
- Hematopoietin 1
see all -
Function
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. -
Sequence similarities
Belongs to the IL-1 family. -
Domain
The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function. -
Cellular localization
Secreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. - Information by UniProt
