Recombinant mouse CD40 protein (Fc Chimera) (ab220449)
Key features and details
- Expression system: HEK 293 cells
- Purity: > 90% SDS-PAGE
- Endotoxin level:
- Active: Yes
- Tags: Fc tag C-Terminus
- Suitable for: Functional Studies, SDS-PAGE
Preparation and Storage
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Alternative names
- AI326936
- B cell associated molecule CD40
- B cell surface antigen CD40
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Function
Receptor for TNFSF5/CD40LG. -
Tissue specificity
B-cells and in primary carcinomas. -
Involvement in disease
Defects in CD40 are the cause of hyper-IgM immunodeficiency syndrome type 3 (HIGM3) [MIM:606843]; also known as hyper-IgM syndrome 3. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation. -
Sequence similarities
Contains 4 TNFR-Cys repeats. -
Cellular localization
Secreted and Cell membrane. - Information by UniProt
Images
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Functional Studies - Recombinant mouse CD40 protein (Fc Chimera) (ab220449)
Immobilized ab220449 at 2 μg/mL (100 μL/well) can bind recombinant mouse TRAP/CD40L protein (Active) (ab220551) with a linear range of 9-78 ng/mL.
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SDS-PAGE - Recombinant mouse CD40 protein (Fc Chimera) (ab220449)SDS-PAGE analysis of reduced ab220449 stained overnight with Coomassie Blue.
The reducing protein migrates as 57 kDa in SDS-PAGE due to glycosylation.
