Recombinant Mouse CCL4/MIP-1 beta protein (ab209135)
Key features and details
- Expression system: Yeast
- Suitable for: SDS-PAGE
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Product name
Recombinant Mouse CCL4/MIP-1 beta protein
See all CCL4/MIP-1 beta proteins and peptides -
Expression system
Yeast -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Mouse -
Sequence
APMGSDPPTS CCFSYTSRQL HRSFVMDYYE TSSLCSKPAV VFLTKRGRQI CANPSEPWVT EYMSDLELN -
Predicted molecular weight
8 kDa -
Amino acids
24 to 92 -
Additional sequence information
Mature full length protein: signal peptide not included. Produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
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Preparation and Storage
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Alternative names
- MIP 1 beta
- Secreted protein G 26
- ACT 2
see all -
Function
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. -
Sequence similarities
Belongs to the intercrine beta (chemokine CC) family. -
Post-translational
modificationsN-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes. -
Cellular localization
Secreted. - Information by UniProt
