Recombinant Human VEGFD protein (ab209363)
Key features and details
- Expression system: Yeast
- Suitable for: SDS-PAGE
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Product name
Recombinant Human VEGFD protein
See all VEGFD proteins and peptides -
Expression system
Yeast -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
FAATFYDIET LKVIDEEWQR TQCSPRETCV EVASELGKST NTFFKPPCVN VFRCGGCCNE ESLICMNTST SYISKQLFEI SVPLTSVPEL VPVKVANHTG CKCLPTAPRH PYSIIRR -
Predicted molecular weight
13 kDa -
Amino acids
89 to 205 -
Additional sequence information
Mature full lenght without propetides and signal peptide. Produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
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Preparation and Storage
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Alternative names
- c-fos induced growth factor
- c-fos induced growth factor (vascular endothelial growth factor D)
- c-fos-induced growth factor
see all -
Function
Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. -
Tissue specificity
Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas. -
Sequence similarities
Belongs to the PDGF/VEGF growth factor family. -
Post-translational
modificationsUndergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions. -
Cellular localization
Secreted. - Information by UniProt
