Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant Human TREM1 protein (Fc Chimera) (ab245788)

Key features and details

  • Expression system: CHO cells
  • Purity: > 95% SDS-PAGE
  • Endotoxin level:
  • Tags: Fc tag C-Terminus
  • Suitable for: SDS-PAGE, HPLC

Description

  • Product name

    Recombinant Human TREM1 protein (Fc Chimera)
    See all TREM1 proteins and peptides

  • Purity

    > 95 % SDS-PAGE.
    >95% by HPLC.

  • Endotoxin level

  • Expression system

    CHO cells

  • Accession

    Q9NP99

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      ATKLTEEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRDGEMPKTLACT ERPSKNSHPVQVGRIILEDYHDHGLLRVRMVNLQVEDSGLYQCVIYQPPK EPHMLFDRIRLVVTKGFSGTPGSNENSTQNVYKIPPTTTKALCPLYTSPR TVTQAPPKSTADVSTPDSEINLTNVTDIIRGGPKSCDKTHTCPPCPAPEL LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV HNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEK TISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESN GQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHN HYTQKSLSLSPGK

    • Predicted molecular weight

      46 kDa including tags

    • Amino acids

      21 to 200

    • Tags

      Fc tag C-Terminus

    • Associated products

      Specifications

      Our Abpromise guarantee covers the use of ab245788 in the following tested applications.

      The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

      • Applications

        SDS-PAGE

        HPLC

      • Form

        Lyophilized
      • Concentration information loading...

      Preparation and Storage

      • Stability and Storage

        Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

        Sterile filtered through a 0.2 micron filter. Lyophilized from 10mM Sodium Phosphate.

      • Reconstitution
        Centrifuge vial prior to opening. Reconstitute in water to 0.1-1.0 mg/ml. Do not vortex. Store at 2°C to 8°C for 1 week, or prepare for extended storage.

      General Info

      • Alternative names

        • CD354
        • OTTMUSP00000018206
        • TREM 1
        • TREM-1
        • TREM1
        • TREM1_HUMAN
        • Triggering receptor expressed on monocytes 1
        • Triggering receptor expressed on myeloid cells 1
        • Triggering receptor TREM 1
        • Triggering receptor TREM1
        see all

      • Function

        Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.

      • Tissue specificity

        Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes.

      • Sequence similarities

        Contains 1 Ig-like V-type (immunoglobulin-like) domain.

      • Post-translational
        modifications

        Glycosylated.

      • Cellular localization

        Secreted and Cell membrane.
      • Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab245788? Please let us know so that we can cite the reference in this datasheet.

    ab245788 has not yet been referenced specifically in any publications.

    Preparation and Storage

    • Alternative names

      • CD354
      • OTTMUSP00000018206
      • TREM 1
      • TREM-1
      • TREM1
      • TREM1_HUMAN
      • Triggering receptor expressed on monocytes 1
      • Triggering receptor expressed on myeloid cells 1
      • Triggering receptor TREM 1
      • Triggering receptor TREM1
      see all

    • Function

      Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.

    • Tissue specificity

      Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes.

    • Sequence similarities

      Contains 1 Ig-like V-type (immunoglobulin-like) domain.

    • Post-translational
      modifications

      Glycosylated.

    • Cellular localization

      Secreted and Cell membrane.
    • Information by UniProt

    Images

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