Recombinant Human PAPP A protein (ab53389)
Key features and details
- Expression system: Escherichia coli
- Purity: > 95% SDS-PAGE
- Suitable for: SDS-PAGE
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Product name
Recombinant Human PAPP A protein
See all PAPP A proteins and peptides -
Purity
> 95 % SDS-PAGE. -
Expression system
Escherichia coli -
Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
-
Species
Human -
Sequence
REARGATEEP SPPSRALYFS GRGEQLRLRA DLELPRDAFT LQVWLRAEGG QRSPAVITGL YDKCSYISRD RGWVVGIHTI SDQDNKDPRY FFSLKTDRAR QVTTINAHRS YLPGQWVYLA ATYDGQFMKL YVNGAQVATS GEQVGGIFSP LTQKCKVLML GGSALNHNYR GYIEHFSLWK VARTQREILS -
Amino acids
81 to 271
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Preparation and Storage
-
Alternative names
- ASBABP2
- Aspecific BCL2 ARE binding protein 2
- Differentially placenta 1 expressed protein
see all -
Function
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. -
Tissue specificity
High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts. -
Sequence similarities
Belongs to the peptidase M43B family.
Contains 5 Sushi (CCP/SCR) domains. -
Developmental stage
Present in serum and placenta during pregnancy; levels increase throughout pregnancy. -
Post-translational
modificationsThere appear to be no free sulfhydryl groups. -
Cellular localization
Secreted. - Information by UniProt
Images
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SDS-PAGE - Recombinant Human PAPP A protein (ab53389)SDS PAGE analysis of ab53389.