Recombinant Human Neurturin protein (ab9840)
Key features and details
- Expression system: Escherichia coli
- Endotoxin level:
- Suitable for: SDS-PAGE, Functional Studies
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Product name
Recombinant Human Neurturin protein -
Endotoxin level
Expression system
Escherichia coliProtein length
Full length proteinAnimal free
NoNature
Recombinant-
Species
Human -
Predicted molecular weight
22 kDa
Specifications
Our Abpromise guarantee covers the use of ab9840 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
Functional Studies
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Form
Lyophilized -
Additional notes
Human Neurturin is fully biologically active when compared to standards. Human Neurturin at a concentration of 100ng/ml will support the survival of 65% of newborn rat sympathetic neurons. -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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ReconstitutionReconstitute in water to a concentration of 0.1mg/ml
General Info
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Alternative names
- Neurturin
- Neurturin precursor
- NRTN
see all -
Function
Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. -
Involvement in disease
Defects in NRTN are a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, and possibly with other loci, defects in NRTN are involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. -
Sequence similarities
Belongs to the TGF-beta family. GDNF subfamily. -
Cellular localization
Secreted. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
References (0)
ab9840 has not yet been referenced specifically in any publications.
Preparation and Storage
- Neurturin
- Neurturin precursor
- NRTN
