• Product name

  Recombinant human MMP3 protein
  See all MMP3 proteins and peptides

• Biological activity

  The specific activity of ab134448 was >1000 mU/mg when assayed with the synthetic substrate (7-methoxycoumarin-4yl) acetyl-Arg-Pro-Lys-Pro-ValGlu-Nva-Trp-Arg-Lys (Dnp) - NH₂.

• Purity

  > 90 % SDS-PAGE.
  
  

• Expression system

  Escherichia coli

• Accession

  P08254

• Protein length

  Protein fragment

• Animal free

  No

• Nature

  Recombinant

• • Species

    Human

  • Predicted molecular weight

    22 kDa

  • Amino acids

    100 to 273

• Alternative names

  • CHDS6
  • Matrix metalloproteinase 3
  • Matrix metalloproteinase 3 preproprotein

  • Matrix metalloproteinase-3
  • MGC126102
  • MGC126103
  • MGC126104
  • MMP 3
  • MMP-3
  • MMP3
  • MMP3_HUMAN
  • Proteoglycanase
  • SL-1
  • SL1
  • STMY
  • STMY1
  • STR1
  • Stromelisin 1
  • Stromelysin 1
  • Stromelysin 1 progelatinase
  • Stromelysin-1
  • Transin 1
  • Transin-1

  see all

• Function

  Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.

• Sequence similarities

  Belongs to the peptidase M10A family.
  Contains 4 hemopexin-like domains.

• Domain

  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

• Cellular localization

  Secreted > extracellular space > extracellular matrix.

• Target information above from: UniProt accession P08254 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt