Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant Human IL-21R protein (Fc Chimera) (ab214127)

Key features and details

  • Expression system: CHO cells
  • Purity: >= 98% SDS-PAGE
  • Endotoxin level:
  • Suitable for: SDS-PAGE

Description

  • Product name

    Recombinant Human IL-21R protein (Fc Chimera)
    See all IL-21R proteins and peptides

  • Purity

    >= 98 % SDS-PAGE.

  • Endotoxin level

  • Expression system

    CHO cells

  • Accession

    Q9HBE5

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      CPDLVCYTDYLQTVICILEMWNLHPSTLTLTWQDQYEELKDEATSCSLHR SAHNATHATYTCHMDVFHFMADDIFSVNITDQSGNYSQECGSFLLAESIK PAPPFNVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYELQYRNRGDPWAV SPRRKLISVDSRSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWSD PVIFQTQSEELKE

    • Predicted molecular weight

      25 kDa

    • Amino acids

      20 to 232

    • Additional sequence information

      The extracellular domain of Human IL-21Receptor fused to the N-terminus of the Fc region of Human IgG1 (NP_851564.1).

    • Associated products

    Specifications

    Our Abpromise guarantee covers the use of ab214127 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Lyophilized
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C. Avoid freeze / thaw cycle.

      Constituent: 100% PBS

      0.2µm-filtered.

    • Reconstitution
      Reconstitute with 100 µl sterile water. Add 1X PBS to the desired protein concentration.

    General Info

    • Alternative names

      • CD360
      • IL 21R
      • IL-21 receptor
      • IL-21R
      • IL21 receptor
      • IL21R
      • IL21R_HUMAN
      • Interleukin 21 receptor
      • Interleukin-21 receptor
      • MGC10967
      • NILR
      • Novel interleukin receptor
      see all

    • Function

      This is a receptor for interleukin-21.

    • Tissue specificity

      Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.

    • Sequence similarities

      Belongs to the type I cytokine receptor family. Type 4 subfamily.
      Contains 2 fibronectin type-III domains.

    • Domain

      The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
      The box 1 motif is required for JAK interaction and/or activation.

    • Post-translational
      modifications

      C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame.

    • Cellular localization

      Membrane.
    • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab214127? Please let us know so that we can cite the reference in this datasheet.

ab214127 has not yet been referenced specifically in any publications.

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C. Avoid freeze / thaw cycle.

    Constituent: 100% PBS

    0.2µm-filtered.

  • Reconstitution
    Reconstitute with 100 µl sterile water. Add 1X PBS to the desired protein concentration.

Images

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