Recombinant Human IL-2 Receptor alpha protein (Fc Chimera) (ab200511)
Key features and details
- Expression system: HEK 293 cells
- Purity: > 95% SDS-PAGE
- Endotoxin level:
- Tags: Fc tag C-Terminus
- Suitable for: SDS-PAGE
Preparation and Storage
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Alternative names
- Interleukin 2 receptor alpha chain
- CD25
- CD25 antigen
see all -
Function
Receptor for interleukin-2. -
Involvement in disease
Genetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:601942]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. -
Sequence similarities
Contains 2 Sushi (CCP/SCR) domains. -
Cellular localization
Membrane. - Information by UniProt
Images
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SDS-PAGE - Recombinant Human IL-2 Receptor alpha protein (Fc Chimera) (ab200511)
The purity of ab200511 was determined by DTT-reduced SDS-PAGE and staining overnight with Coomassie Blue. DTT-reduced protein migrates as 60-75 kDa in SDS-PAGE due to glycosylation.
