Recombinant human ICAM1 protein (ab168688)
Key features and details
- Expression system: HEK 293 cells
- Purity: > 98% SDS-PAGE
- Endotoxin level:
- Active: Yes
- Tags: Fc tag C-Terminus
- Suitable for: Functional Studies, SDS-PAGE
Preparation and Storage
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Alternative names
- Antigen identified by monoclonal antibody BB2
- BB 2
- BB2
see all -
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus. -
Sequence similarities
Belongs to the immunoglobulin superfamily. ICAM family.
Contains 5 Ig-like C2-type (immunoglobulin-like) domains. -
Post-translational
modificationsMonoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. -
Cellular localization
Membrane. - Information by UniProt
Images
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SDS-PAGE - Recombinant human ICAM1 protein (ab168688)Human ICAM-1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 98%.
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Functional Studies - Recombinant human ICAM1 protein (ab168688)Immobilized Human ITGALB2, His tag at 5 µg/mL (100 µL/well) can bind Human ICAM-1, Fc Tag with a linear range of 0.082-1.28 µg/mL. -
SDS-PAGE - Recombinant human ICAM1 protein (ab168688)SDS-PAGE analysis of reduced ab168688 stained overnight with Coomassie Blue.
Protein migrates as 100-110 kDa in reduced SDS-PAGE resulting from glycosylation.
