Antibodies, Proteins, Kits and Reagents for Life Science

Key features and details

Expression system: CHO cells
Purity: >= 98% SDS-PAGE
Endotoxin level:
Active: Yes
Suitable for: SDS-PAGE, Functional Studies

Alternative names
- Antigen identified by monoclonal antibody BB2
- BB 2
- BB2
- CD 54
- CD_antigen=CD54
- CD54
- Cell surface glycoprotein P3.58
- Human rhinovirus receptor
- ICAM 1
- ICAM-1
- ICAM1
- ICAM1_HUMAN
- Intercellular adhesion molecule 1
- intercellular adhesion molecule 1 (CD54)
- intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
- Major group rhinovirus receptor
- MALA 2
- MALA2
- MyD 10
- MyD10
- P3.58
- Surface antigen of activated B cells
- Surface antigen of activated B cells, BB2
see all
Function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
Sequence similarities

Belongs to the immunoglobulin superfamily. ICAM family.
Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Post-translational
modifications

Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
Cellular localization

Membrane.
Target information above from: UniProt accession P05362 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

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