• Product name

  Recombinant Human Cyclin E1 protein

• Purity

  > 90 % SDS-PAGE.
  Purity tested by densitometry.
  

• Expression system

  Baculovirus infected Sf9 cells

• Accession

  P24864

• Protein length

  Full length protein

• Animal free

  No

• Nature

  Recombinant

• • Species

    Human

  • Predicted molecular weight

    73 kDa including tags

  • Amino acids

    1 to 410

• Alternative names

  • CCNE
  • Ccne1
  • CCNE1_HUMAN

  • cyclin E variant ex5del
  • cyclin E variant ex7del
  • Cyclin E1
  • Cyclin Es
  • Cyclin Et
  • CyclinE
  • G1/S specific cyclin E
  • G1/S-specific cyclin-E1

  see all

• Function

  Essential for the control of the cell cycle at the G1/S (start) transition.

• Tissue specificity

  Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.

• Sequence similarities

  Belongs to the cyclin family. Cyclin E subfamily.

• Post-translational
  modifications

  Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR.

• Cellular localization

  Nucleus.

• Target information above from: UniProt accession P24864 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt