Recombinant Human CD4 protein (Tagged) (ab271458)
Key features and details
- Expression system: Baculovirus infected Sf9 cells
- Purity: >= 90% SDS-PAGE
- Tags: DDDDK tag N-Terminus
- Suitable for: SDS-PAGE
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Product name
Recombinant Human CD4 protein (Tagged)
See all CD4 proteins and peptides -
Purity
>= 90 % SDS-PAGE. -
Expression system
Baculovirus infected Sf9 cells -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
ATSRYEPVAE IGVGAYGTVY KARDPHSGHF VALKSVRVPN GGGGGGGLPI STVREVALLR RLEAFEHPNV VRLMDVCATS RTDREIKVTL VFEHVDQDLR TYLDKAPPPG LPAETIKDLM RQFLRGLDFL HANCIVHRDL KPENILVTSG GTVKLADFGL ARIYSYQMAL TPVVVTLWYR APEVLLQSTY ATPVDMWSVG CIFAEMFRRK PLFCGNSEAD QLGKIFDLIG LPPEDDWPRD VSLPRGAFPP RGPRPVQSVV PEMEESGAQL LLEMLTFNPH KRISAFRALQ HSYLHKDEGN PE -
Predicted molecular weight
36 kDa including tags -
Amino acids
2 to 303 -
Tags
DDDDK tag N-Terminus -
Additional sequence information
Genbank: NM_000075
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Preparation and Storage
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Alternative names
- CD 4
- CD4
- CD4 (L3T4)
see all -
Function
Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. -
Sequence similarities
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
Post-translational
modificationsPalmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts. -
Cellular localization
Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum. - Information by UniProt
Images
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SDS-PAGE - Recombinant Human CD4 protein (Tagged) (ab271458)SDS-PAGE analysis of ab271458.
