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Recombinant Human CD4 protein (Tagged) (ab271458)

Key features and details

  • Expression system: Baculovirus infected Sf9 cells
  • Purity: >= 90% SDS-PAGE
  • Tags: DDDDK tag N-Terminus
  • Suitable for: SDS-PAGE

Description

  • Product name

    Recombinant Human CD4 protein (Tagged)
    See all CD4 proteins and peptides

  • Purity

    >= 90 % SDS-PAGE.

  • Expression system

    Baculovirus infected Sf9 cells

  • Accession

    P11802

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      ATSRYEPVAE IGVGAYGTVY KARDPHSGHF VALKSVRVPN GGGGGGGLPI STVREVALLR RLEAFEHPNV VRLMDVCATS RTDREIKVTL VFEHVDQDLR TYLDKAPPPG LPAETIKDLM RQFLRGLDFL HANCIVHRDL KPENILVTSG GTVKLADFGL ARIYSYQMAL TPVVVTLWYR APEVLLQSTY ATPVDMWSVG CIFAEMFRRK PLFCGNSEAD QLGKIFDLIG LPPEDDWPRD VSLPRGAFPP RGPRPVQSVV PEMEESGAQL LLEMLTFNPH KRISAFRALQ HSYLHKDEGN PE

    • Predicted molecular weight

      36 kDa including tags

    • Amino acids

      2 to 303

    • Tags

      DDDDK tag N-Terminus

    • Additional sequence information

      Genbank: NM_000075

Preparation and Storage

  • Alternative names

    • CD 4
    • CD4
    • CD4 (L3T4)
    • CD4 antigen
    • CD4 antigen (p55)
    • CD4 molecule
    • CD4 receptor
    • CD4+ Lymphocyte deficiency, included
    • CD4_HUMAN
    • CD4mut
    • L3T4
    • Leu3
    • Ly-4
    • Lymphocyte antigen CD4
    • MGC165891
    • OTTHUMP00000238897
    • p55
    • T cell antigen T4
    • T cell antigen T4/LEU3
    • T cell differentiation antigen L3T4
    • T cell OKT4 deficiency, included
    • T cell surface antigen T4/Leu 3
    • T cell surface antigen T4/Leu3
    • T cell surface glycoprotein CD4
    • T-cell surface antigen T4/Leu-3
    • T-cell surface glycoprotein CD4
    • W3/25
    • W3/25 antigen
    see all

  • Function

    Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.

  • Sequence similarities

    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.

  • Post-translational
    modifications

    Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.

  • Cellular localization

    Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human CD4 protein (Tagged) (ab271458)
    SDS-PAGE - Recombinant Human CD4 protein (Tagged) (ab271458)
    SDS-PAGE analysis of ab271458.

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