Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant Human CD32B protein (ab152084)

Key features and details

  • Expression system: HEK 293 cells
  • Purity: > 95% SDS-PAGE
  • Endotoxin level:
  • Tags: His tag C-Terminus
  • Suitable for: SDS-PAGE, HPLC

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -80°C.

    pH: 7.20
    Constituents: 99% Phosphate Buffer, 0.88% Sodium chloride

  • Reconstitution
    Lyophilized from a 0.2 µM filtered solution. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. Dissolve the lyophilized protein in 1X PBS. It is not recommended to reconstitute to a concentration less than 100 µg/ml.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at

    General Info

    • Alternative names

      • CD32
      • CD32 antigen
      • CD32B
      • CDw32
      • Fc fragment of IgG, low affinity II, receptor for (CD32)
      • Fc fragment of IgG, low affinity IIb, receptor
      • Fc fragment of IgG, low affinity IIb, receptor (CD32)
      • Fc fragment of IgG, low affinity IIb, receptor for
      • Fc fragment of IgG, low affinity IIb, receptor for (CD32)
      • Fc gamma receptor IIB
      • Fc gamma RII
      • Fc gamma RIIB
      • Fc-gamma RII
      • Fc-gamma RII-b
      • Fc-gamma-RIIb
      • FCG2
      • FCG2B_HUMAN
      • Fcgr2
      • FCGR2B
      • FCRII
      • FcRII-b
      • IGFR2
      • IgG Fc receptor II beta
      • IgG Fc receptor II-b
      • Low affinity immunoglobulin gamma Fc region receptor II
      • Low affinity immunoglobulin gamma Fc region receptor II-b
      • Ly-17
      • Lym 1
      • Lymphocyte antigen 17
      see all

    • Function

      Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

    • Tissue specificity

      Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.

    • Involvement in disease

      Note=A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression.

    • Sequence similarities

      Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

    • Domain

      Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

    • Cellular localization

      Cell membrane.
    • Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

References (0)

Publishing research using ab152084? Please let us know so that we can cite the reference in this datasheet.

ab152084 has not yet been referenced specifically in any publications.

Images

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Alternative products to Recombinant Human CD32B protein (ab152084)

Get resources and offers direct to your inbox Sign up