Sivelestat, neutrophil elastase inhibitor (ab146184)
Key features and details
- Potent, selective, substrate competitive neutrophil elastase inhibitor
- CAS Number: 127373-66-4
- Soluble in DMSO
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Sivelestat, neutrophil elastase inhibitor -
Description
Potent, selective, substrate competitive neutrophil elastase inhibitor -
Biological description
Potent, selective, substrate competitive neutrophil elastase inhibitor (IC50 values are 19-49 nM and 5.6 μM for leukocyte and pancreas elastase respectively). Suppresses neutrophil-induced capillary permeability and leukocyte kinetics. Active in vivo. -
CAS Number
127373-66-4 -
Chemical structure
Properties
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Chemical name
2-[[2-[[4-(2,2-Dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid -
Molecular weight
434.46 -
Molecular formula
C20H22N2O7S -
PubChem identifier
107706 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O -
Source
Synthetic
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Research areas