Antibodies, Proteins, Kits and Reagents for Life Science

Key features and details

Expression system: Escherichia coli
Purity: > 95% SDS-PAGE
Active: Yes
Suitable for: SDS-PAGE, Functional Studies

Product name

Recombinant human BAFF protein (Animal Free)
See all BAFF proteins and peptides
Biological activity

Determined by a mouse splenocyte survival assay. The expected ED₅₀ for this effect is 0.5-2.0 µg/ml.
Purity

> 95 % SDS-PAGE.
assessed also by HPLC
Expression system

Escherichia coli
Accession

Q9Y275
Protein length

Full length protein
Animal free

Yes
Nature

Recombinant
- Species
  
  Human
- Sequence
  
  AVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKEN KILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCI QNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALK LL
- Predicted molecular weight
  
  17 kDa
- Amino acids
  
  134 to 285
- Additional sequence information
  
  mature full length containing the TNF-like portion of the extracellular domain

Alternative names
- ApoL related ligand TALL 1
- B cell Activating Factor
- B lymphocyte stimulator
- B-cell-activating factor
- BAFF
- BLyS
- CD 257
- CD257
- CD257 antigen
- Delta BAFF
- Dendritic cell derived TNF like molecule
- Dendritic cell-derived TNF-like molecule
- DTL
- DTL precursor
- PRO738
- soluble form
- TALL 1
- TALL-1
- TALL1
- THANK
- TN13B_HUMAN
- TNF and APOL related leukocyte expressed ligand 1
- TNF homolog that activates apoptosis
- TNF homolog that activates apoptosis NKFB and JNK.
- TNF- and APOL-related leukocyte expressed ligand 1
- TNFSF13B
- TNFSF20
- TNLG7A
- Tumor necrosis factor (ligand) superfamily member 13b
- Tumor necrosis factor ligand 7A
- Tumor necrosis factor ligand superfamily member 13b
- Tumor necrosis factor ligand superfamily member 20
- Tumor necrosis factor like protein ZTNF4
- Tumor necrosis factor superfamily member 13B
- UNQ401
- ZTNF4
see all
Function

Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B-and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
Tissue specificity

Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas.
Sequence similarities

Belongs to the tumor necrosis factor family.
Post-translational
modifications

The soluble form derives from the membrane form by proteolytic processing.
N-glycosylated.
Cellular localization

Secreted and Cell membrane.
Target information above from: UniProt accession Q9Y275 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

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