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Cancer Invasion/microenvironment Apoptosis Caspases

Q-DEVD-OPh, caspase-3 inhibitor (ab142037)

Q-DEVD-OPh, caspase-3 inhibitor (ab142037)
  • ChIP - Anti-Histone H3 antibody - Nuclear Loading Control and ChIP Grade (ab1791)
  • ChIP - Anti-Histone H3 antibody - Nuclear Loading Control and ChIP Grade (ab1791)

Key features and details

  • Potent, irreversible, cell-permeable caspase-3 inhibitor
  • CAS Number:
  • Purity: > 90%
  • Soluble in DMSO
  • Form / State: Solid
  • Source: Synthetic

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Overview

  • Product name

    Q-DEVD-OPh, caspase-3 inhibitor
  • Description

    Potent, irreversible, cell-permeable caspase-3 inhibitor
  • Biological description

    Potent, irreversible, cell-permeable caspase-3 inhibitor
  • Purity

    > 90%
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    799.77
  • Molecular formula

    C38H43F2N5O12
  • Sequence

    DEVD (Modifications: N-terminal quinolyl; C-terminal OPh; Asp-1 = Asp(OMe); Glu-2 = Glu(OMe); Asp-4 = Asp(OMe))
  • PubChem identifier

    44135278
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)C(C(=O)NC(CC(=O)OC)C(=O)COC1=C(C=CC=C1F)F)NC(=O)C(CCC(=O)OC)NC(=O)C(CC(=O)OC)NC(=O)C2=NC3=CC=CC=C3C=C2
  • Source

    Synthetic

  • Research areas

    • Cell Biology
    • Apoptosis
    • Intracellular
    • Caspases etc
    • Caspases
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Pharmacology
    • Enzymes
    • Caspase
    • Biochemicals
    • Pharmacology
    • Signaling
    • Apoptosis & cell cycle
    • Caspase

Images

  • Functional Studies - Q-DEVD-OPh, caspase-3 inhibitor (ab142037)
    Functional Studies - Q-DEVD-OPh, caspase-3 inhibitor (ab142037)
    Titration of the Caspase 3 specific inhibitor Q-DEVD-OPh (ab142037) (duplicates; +/- SD).
  • Functional Studies - Q-DEVD-OPh, caspase-3 inhibitor (ab142037)
    Functional Studies - Q-DEVD-OPh, caspase-3 inhibitor (ab142037)

    Functional assays: Caspase 9 Inhibitor Drug Detection Kit (ab102497) Titration of the caspase inhibitors Z-VAD(OMe)-FMK (ab120487) and Q-LEHD-Oph (ab142039) (duplicates; +/- SD).

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

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