PX-866, PI3-kinase inhibitor (ab142172)
Key features and details
- Potent, irreversible PI3-kinase inhibitor
- CAS Number: 502632-66-8
- Purity: > 98%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
PX-866, PI3-kinase inhibitor -
Description
Potent, irreversible PI3-kinase inhibitor -
Alternative names
- DJM-166
- DJM-2-166
- Sonolisib
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Biological description
Potent, irreversible PI3-kinase inhibitor. Inhibits purified phosphoinositide (PtdIns)-3-kinase (IC50 = 0.1 nM) and PtdIns-3-kinase signaling as assessed by phospho-Ser473-Akt levels in HT-29 colon cancer cells (IC50 = 20 nM). Ring-
opened analog of wortmannin (ab120148). Displays antitumor activity. -
Purity
> 98% -
CAS Number
502632-66-8 -
Chemical structure
Properties
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Chemical name
[(3aR,6E,9S,9aR,10R,11aS)-6-[[Bis(prop-2-enyl)amino]methylidene]-5-hydroxy-9-(methoxymethyl)-9a,11a-dimethyl-1,4,7-trioxo-2,3,3a,9,10,11-hexahydroindeno[4,5-h]isochromen-10-yl] acetate -
Molecular weight
525.59 -
Molecular formula
C29H35NO8 -
PubChem identifier
9849735 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](OC(=O)/C(=C/N(CC=C)CC=C)/C4=C(C3=O)O)COC)C)C -
Source
Synthetic
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Research areas
- Epigenetics and Nuclear Signaling
- DNA / RNA
- DNA Damage & Repair
- DNA Damage Response
- DNA Damage Recognition
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
