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PICK1 peptide (ab4964)

Key features and details

  • Suitable for: Blocking

Description

Preparation and Storage

  • Alternative names

    • dJ1039K5
    • MGC15204
    • OTTHUMP00000028509
    • PICK 1
    • Pick1
    • PICK1_HUMAN
    • PRKCA binding protein
    • PRKCA-binding protein
    • PRKCABP
    • Protein interacting with C kinase 1
    • Protein interacting with PRKCA
    • Protein interacting with PRKCA 1
    • Protein kinase C alpha binding protein
    • Protein kinase C-alpha-binding protein
    • Protein that interacts with C kinase 1
    see all

  • Function

    Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ACCN3/ACCN2 channel.

  • Tissue specificity

    Ubiquitous.

  • Sequence similarities

    Contains 1 AH domain.
    Contains 1 PDZ (DHR) domain.

  • Post-translational
    modifications

    Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors.

  • Cellular localization

    Cytoplasm > perinuclear region. Cell junction > synapse. Also present at excitatory synapses.
  • Information by UniProt

Images

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