Phrixotoxin-1, Specific Kv4.3 and Kv4.2 channel blocker (ab141844)
Key features and details
- Specific Kv4.3 and Kv4.2 channel blocker
- CAS Number: 221872-97-5
- Purity: > 98%
- Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Phrixotoxin-1, Specific Kv4.3 and Kv4.2 channel blocker -
Description
Specific Kv4.3 and Kv4.2 channel blocker -
Biological description
Potent Kv4.2 and Kv4.3 potassium channel inhibitor (IC50 values are 5 and 28 nM, respectively). -
Purity
> 98% -
CAS Number
221872-97-5 -
Chemical structure
Properties
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Chemical name
YCQKWMWTCDSARKCCEGLVCRLWCKKII (Modifications: Ile-29= C-terminal amide; Disulfide bridges: 2-16, 9-21 and 15-25) -
Molecular weight
3549.00 -
Molecular formula
C156H240N44O37S7 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min). -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
Images
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Functional Studies - Phrixotoxin-1, Specific Kv4.3 and Kv4.2 channel blocker (ab141844)Phrixotoxin-1 inhibits KV4.2 currents expressed in Xenopus oocytes.
KV4.2 channel currents were recorded using two electrode voltage clamp, with ND 96 in the bath solution. From a holding potential of -100 mV to -10 mV, a 100 ms depolarization was applied every 10 sec in the before (black) or during (green) the application of 100 nM Phrixotoxin-1 (ab141844).