Phortress, Antitumor agent (ab144638)
Key features and details
- Potent antitumor agent
- CAS Number: 328087-38-3
- Purity: > 98%
- Soluble in water to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Phortress, Antitumor agent -
Description
Potent antitumor agent -
Biological description
Potent antitumor agent (IC50 values for MCF-7 and MDA468 cells are 40 nM and 158 nM, respectively). Active against breast, ovarian and renal carcinomas. Taken up into sensitive cells followed by aryl hydrocarbon receptor binding and translocation into the nucleus. Requires metabolic activation by cytochrome P450 to generate cytotoxic species. Active in vitro and in vivo. Water soluble.
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Purity
> 98% -
General notes
Sold under license from CRT -
CAS Number
328087-38-3 -
Chemical structure
Properties
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Chemical name
(2S)-2,6-Diamino-N-[4-(5-fluoro-1,3-benzothiazol-2-yl)-2-methylphenyl]hexanamide dihydrochloride -
Molecular weight
459.41 -
Molecular formula
C20H23FN4OS.2HCl -
PubChem identifier
9804228 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Cl.NCCCC[C@H](N)C(=O)Nc1ccc(cc1C)c2nc3cc(F)ccc3s2 -
Source
Synthetic
