PFI-3, bromodomain and SMARCA4 inhibitor (ab223602)
Key features and details
- Potent and selective bromodomain and SMARCA4 inhibitor
- CAS Number: 1819363-80-8
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
PFI-3, bromodomain and SMARCA4 inhibitor -
Description
Potent and selective bromodomain and SMARCA4 inhibitor -
Biological description
Potent and selective inhibitor of Polybromo (Kd = 48 nM) and SMARCA4 (Kd = 89 nM). Also inhibits SMARCA2. Displays high specificity for Family VIII bromodomains. PFI-3 displays selectivity against a range of other kinases. In a panel of 103 receptors and enzymes, activity was observed only against 4 GPCRs. At a concentration of 1 μM, PFI-3 accelerates FRAP recovery in cells.
-
Purity
> 98% -
General notes
Protect from air.
-
CAS Number
1819363-80-8 -
Chemical structure
Properties
-
Chemical name
(E)-1-(2-Hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one -
Molecular weight
321.37 -
Molecular formula
C19H19N3O2 -
PubChem identifier
78243717 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store In the Dark. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
C1[C@@H]2CN([C@H]1CN2C3=CC=CC=N3)/C=C/C(=O)C4=CC=CC=C4O -
Source
Synthetic
-
Research areas
