• Product name

  PDE4D peptide
  See all PDE4D proteins and peptides

• Animal free

  No

• Nature

  Synthetic

• Alternative names

  • cAMP specific 3',5' cyclic phosphodiesterase 4D
  • DKFZp686M11213
  • 5''-cyclic phosphodiesterase 4D

  • cAMP specific phosphodiesterase 4D
  • cAMP specific phosphodiesterase PDE4D6
  • cAMP-specific 3''
  • DPDE3
  • Dunce like phosphodiesterase E3
  • FLJ97311
  • HSPDE4D
  • PDE43
  • Pde4d
  • PDE4D_HUMAN
  • PDE4DN2
  • Phosphodiesterase 4D cAMP specific
  • Phosphodiesterase 4D cAMP specific (dunce (Drosophila) homolog phosphodiesterase E3)
  • Phosphodiesterase 4D cAMP specific (phosphodiesterase E3 dunce homolog Drosophila)
  • Phosphodiesterase 4D, cAMP specific (dunce)
  • STRK1

  see all

• Function

  Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

• Tissue specificity

  Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.

• Pathway

  Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.

• Involvement in disease

  Note=Genetic variations in PDE4D might be associated with susceptibility to stroke. PubMed:17006457 states that association with stroke has to be considered with caution.

• Sequence similarities

  Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.

• Post-translational
  modifications

  Isoform 3 and isoform 7 are activated by phosphorylation (in vitro), but not isoform 6. Isoform N3 and isoform 12 are phosphorylated on Ser-49, Ser-51, Ser-55 and Ser-59.

• Cellular localization

  Cytoplasm. Membrane. Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome.

• Target information above from: UniProt accession Q08499 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt