NSC697923, UBE2N inhibitor (ab144316)
Key features and details
- Selective, cell-permeable UBE2N inhibitor
- CAS Number: 343351-67-7
- Purity: > 98%
- Soluble in ethanol to 25 mM (with gentle warming) and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
NSC697923, UBE2N inhibitor -
Description
Selective, cell-permeable UBE2N inhibitor -
Biological description
Selective, cell-permeable UBE2N inhibitor. Inhibits E2 complex Ubc13-Uev1A. Inhibits NF-κB activation. Induces nuclear accumulation of p53 and apoptosis. Shows potent cytotoxic effects to neuroblastoma cell lines. Shows antitumor effects in vivo. -
Purity
> 98% -
CAS Number
343351-67-7 -
Chemical structure
Properties
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Chemical name
2-(4-Methylphenyl)sulfonyl-5-nitrofuran -
Molecular weight
267.26 -
Molecular formula
C11H9NO5S -
PubChem identifier
394449 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in ethanol to 25 mM (with gentle warming) and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(O2)[N+](=O)[O-] -
Source
Synthetic
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Research areas
