Nomifensine maleate, norepinephrine-dopamine reuptake inhibitor (ab146004)
Key features and details
- Potent norepinephrine-dopamine reuptake inhibitor. Antidepressant.
- CAS Number: 32795-47-4
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Nomifensine maleate, norepinephrine-dopamine reuptake inhibitor -
Description
Potent norepinephrine-dopamine reuptake inhibitor. Antidepressant. -
Alternative names
- 2-methyl-4-phenyl-1,2,3,4-tetra
- Merital
- Nomifensine
- Nomifensine maleate salt
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Biological description
Potent inhibitor of norepinephrine and dopamine uptake (Ki values are 4.7, 26 and 4000 nM for inhibition of norepinephrine, dopamine and 5-HT uptake respectively in rat brain). Increases central dopamine levels in rats following systemic administration. Interacts with the dopamine transporter at a site different from that of cocaine. Antidepressant.
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Purity
> 98% -
CAS Number
32795-47-4 -
Chemical structure
Properties
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Chemical name
2-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine maleate -
Molecular weight
354.40 -
Molecular formula
C16H18N2.C4H4O4 -
PubChem identifier
5358907 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1CC(C2=C(C1)C(=CC=C2)N)C3=CC=CC=C3.C(=C\C(=O)O)\C(=O)O -
Source
Synthetic
