Niclosamide, STAT3 inhibitor (ab120868)
Key features and details
- Antihelminthic, anticancer and protonophric agent. STAT3 inhibitor.
- CAS Number: 50-65-7
- Purity: > 95%
- Soluble in ethanol to 0.5 mg/ml
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Niclosamide, STAT3 inhibitor -
Description
Antihelminthic, anticancer and protonophric agent. STAT3 inhibitor. -
Biological description
Antihelminthic, anticancer and protonophric agent. STAT3 inhibitor (IC50 = 0.25 μM). Shown to inhibit a number of downstream signaling pathways including mTORC1, Wnt/β-catinin, NF-κB, notch and ROS. -
Purity
> 95% -
CAS Number
50-65-7 -
Chemical structure
Properties
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Chemical name
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide -
Molecular weight
327.12 -
Molecular formula
C13H8Cl2N2O4 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 0.5 mg/ml -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
OC1=C(C(NC2=CC=C([N+]([O-])=O)C=C2Cl)=O)C=C(Cl)C=C1 -
Source
Synthetic
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Research areas
