NCH 51, HDAC inhibitor (ab120949)
Key features and details
- Novel HDAC inhibitor
- CAS Number: 848354-66-5
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
NCH 51, HDAC inhibitor -
Description
Novel HDAC inhibitor -
Alternative names
- PTACH
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Biological description
Novel HDAC inhibitor (IC50 values are 32, 48 and 41 nM at HDAC4, HDAC1 and HDAC6, respectively). Induces apoptosis and inhibits cell growth of various malignant cells and tumor cells lines (EC50 = 3.8 μM). Also reactivates latent HIV-1 gene expression.
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Purity
> 99% -
CAS Number
848354-66-5 -
Chemical structure
Properties
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Chemical name
2-Methylpropanethioic acid S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester -
Molecular weight
390.56 -
Molecular formula
C20H26N2O2S2 -
PubChem identifier
11395181 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(Nc1nc(cs1)c2ccccc2)CCCCCCSC(=O)C(C)C -
Source
Synthetic
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Research areas
