Native Mouse Vitronectin/S-Protein (ab92727)
Key features and details
- Expression system: Native
- Purity: > 95% SDS-PAGE
- Suitable for: Functional Studies, SDS-PAGE
-
Product name
Native Mouse Vitronectin/S-Protein
See all Vitronectin/S-Protein proteins and peptides -
Purity
> 95 % SDS-PAGE.
ab92727 was prepared from fresh Mouse plasma using urea as a denaturant. -
Expression system
Native -
Protein length
Full length protein -
Animal free
No -
Nature
Native -
-
Species
Mouse
-
Preparation and Storage
-
Alternative names
- Complement S Protein
- Epibolin
- S Protein
see all -
Function
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. -
Tissue specificity
Plasma. -
Sequence similarities
Contains 4 hemopexin repeats.
Contains 1 SMB (somatomedin-B) domain. -
Domain
The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin. -
Post-translational
modificationsSulfated on 2 tyrosine residues.
N- and O-glycosylated.
Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.
It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
Phosphorylation sites are present in the extracellular medium. -
Cellular localization
Secreted, extracellular space. - Information by UniProt
Images
-
SDS-PAGE - Native Mouse Vitronectin/S-Protein (ab92727)10% SDS-PAGE showing ab92727
Lane 1 ab92727 Non-reduced (3µg)
Lane 2 ab92727 Reduced (3µg)
Lane 3 Molecular weight markers
