MTEP hydrochloride, mGlu5 antagonist (ab120035)
Key features and details
- Potent, selective mGlu5 antagonist
- CAS Number: 1186195-60-7
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
MTEP hydrochloride, mGlu5 antagonist -
Description
Potent, selective mGlu5 antagonist -
Biological description
Brain penetrant, potent, selective and non-competitive mGlu5 receptor antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki = 16 nM). In vivo anxiolytic, devoid of side effects seen with MPEP and benzodiazepines. Also available in Kit: mGlu antagonists (ab120322).
Also available in simple stock solutions (ab144485) - add 1 ml of water to get an exact, ready-to-use concentration. -
Purity
> 99% -
CAS Number
1186195-60-7 -
Chemical structure
Properties
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Chemical name
3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride -
Molecular weight
236.72 -
Molecular formula
C11H8N2S.HCl -
PubChem identifier
45073467 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cc2nc(C#Cc1cccnc1)cs2.Cl -
Source
Synthetic
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Research areas