MK-8931, Beta-sectetase inhibitor (ab223883)
Key features and details
- Selective, potent Beta-sectetase inhibitor
- CAS Number: 1286770-55-5
- Purity: > 98%
- Soluble in DMSO to 75 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
MK-8931, Beta-sectetase inhibitor -
Description
Selective, potent Beta-sectetase inhibitor -
Alternative names
- Verubecestat
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Biological description
MK-8931 is a selective, potent Beta-sectetase 1 inhibitor (IC50 = 2.2 nM).
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Purity
> 98% -
General notes
Protect from air and light.
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CAS Number
1286770-55-5 -
Chemical structure
Properties
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Chemical name
(R)-N-(3-(3-Amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoropicolinamide -
Molecular weight
409.41 -
Molecular formula
C17H17F2N5O3S -
PubChem identifier
51352361 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store In the Dark. -
Solubility overview
Soluble in DMSO to 75 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@]1(CS(=O)(=O)N(C(=N1)N)C)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)F)F -
Source
Synthetic
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Research areas
