Mitoglitazone (MSDC-0160), mTOT modulator (ab254494)
Key features and details
- Prototype mTOT-modulating insulin sensitizer
- CAS Number: 146062-49-9
Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Mitoglitazone (MSDC-0160), mTOT modulator -
Description
Prototype mTOT-modulating insulin sensitizer -
Alternative names
- CAY 10415
- MSDC 0160
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Biological description
Prototype mTOT-modulating insulin sensitizer. Exhibits low binding affinity at PPARγ (EC50 = 23.7 μM). Enhances insulin sensitivity and lowers blood-glucose levels in diabetic mouse models. Suppresses gluconeogenesis and lipogenesis in primary hepatocytes. Inhibits mitochondria pyruvate carriers. Increases mitochondrial respiration rates, leading to a reduction in expression of lipogenic enzymes.
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CAS Number
146062-49-9 -
Chemical structure
Properties
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Chemical name
5-[[4-[2-(5-Ethylpyridin-2-yl)-2-oxoethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
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Molecular weight
370.42 -
Molecular formula
C19H18N2O4S -
PubChem identifier
10429242 -
Storage instructions
Shipped at Room Temperature. Store at Room Temperature. -
Solubility overview
Soluble in DMSO to 100 mM
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Handling
Refer to SDS for further information.
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SMILES
CCC1=CN=C(C=C1)C(=O)COC2=CC=C(C=C2)CC3C(=O)NC(=O)S3 -
Source
Synthetic
