Mevastatin, HMG-CoA reductase inhibitor (ab120652)
Key features and details
- Potent HMG-CoA reductase inhibitor
- CAS Number: 73573-88-3
- Purity: > 98%
- Soluble in ethanol to 10 mM and DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Mevastatin, HMG-CoA reductase inhibitor -
Description
Potent HMG-CoA reductase inhibitor -
Alternative names
- Compactin
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Biological description
Potent HMG-CoA reductase inhibitor. Proapoptotic, able to arrest cells in G1 by down-regulation of CDK4, CDK6 and cyclin D1 and up-regulation of p21 and p27.
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Purity
> 98% -
CAS Number
73573-88-3 -
Chemical structure
Images
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Functional Studies - Mevastatin, HMG-CoA reductase inhibitor (ab120652)ab90529 staining cytochrome C in HepG2 cells treated with mevastatin (ab120652), by ICC/IF. Increase of cytochrome C expression correlates with increased concentration of mevastatin, as described in literature.
The cells were incubated at 37°C for 4 hours in media containing different concentrations of ab120652 (mevastatin) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab90529 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
