Lornoxicam, COX-1 and COX-2 inhibitor (ab142907)
Key features and details
- Potent COX-1 and COX-2 inhibitor
- CAS Number: 70374-39-9
- Purity: > 98%
- Soluble in DMSO
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Lornoxicam, COX-1 and COX-2 inhibitor -
Description
Potent COX-1 and COX-2 inhibitor -
Biological description
Potent COX-1 and COX-2 inhibitor (IC50 = 5 and 8 nM for COX-1 and COX-2, respectively). Inhibits IL-6 production and reduces nitric oxide formation. Reduces c-Fos expression in vivo. Orally active. Anti-inflammatory agent. Active in vivo and in vitro. -
Purity
> 98% -
CAS Number
70374-39-9 -
Chemical structure
Properties
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Chemical name
6-Chloro-4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,3-e]thiazine-3-carboxamide -
Molecular weight
371.82 -
Molecular formula
C13H10ClN3O4S2 -
PubChem identifier
54690031 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1C(=C(C2=C(S1(=O)=O)C=C(S2)Cl)O)C(=O)NC3=CC=CC=N3 -
Source
Synthetic
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Research areas