LDN-57444, UCH-L1 inhibitor (ab141487)
Key features and details
- Reversible, competitive UCH-L1 inhibitor
- CAS Number: 668467-91-2
- Purity: > 98%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
LDN-57444, UCH-L1 inhibitor -
Description
Reversible, competitive UCH-L1 inhibitor -
Biological description
Reversible, competitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor (Ki = 0.4 μM. Increases ubiquitinated protein levels and decreases proteasome activity. Also induces apoptosis. -
Purity
> 98% -
CAS Number
668467-91-2 -
Chemical structure
Properties
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Chemical name
[(Z)-[5-Chloro-1-[(2,5-dichlorophenyl)methyl]-2-oxoindol-3-ylidene]amino] acetate -
Molecular weight
397.64 -
Molecular formula
C17H11Cl3N2O3 -
PubChem identifier
16760696 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(=O)ON=C1C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl -
Source
Synthetic
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Research areas
